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England lost to Scotland at Twickenham for the first time since 1983 last weekend, so expect a big response from Eddie Jones’s side on Saturday.
This bet has landed in two of the last three meetings between these sides.
First half handicap: England (-16.5)
England took about 70 minutes to get into the game against Scotland, but that is unlikely to be the case here.
They will look to put Italy under pressure early on, just as France did last weekend when they took a 24-3 lead into the break.
Ben Youngs to score anytime
Youngs has a great try-scoring record against Italy, having dotted down in four of his eight starts against them.
Three of those tries have come in their last two meetings.
George Ford to score anytime
Ford has been reinstated to the starting XV after coming off the bench against Scotland, and he is likely to play a big role on Saturday.
He has two tries in four previous starts against Italy, and will provide a running threat for England from fly-half.